Efficacy of and Patient Compliance with a Ketogenic Diet in Adults with Intractable Epilepsy: A Meta-Analysis
Journal of Clinical Neurology
;
: 26-31, 2015.
Article
in English
| WPRIM
| ID: wpr-150533
ABSTRACT
BACKGROUND AND PURPOSE:
Despite the successful use of a ketogenic diet in pediatric epilepsy, its application in adults has been limited. The aim of this meta-analysis was to summarize the findings of relevant published studies in order to identify the efficacy of and compliance with a ketogenic diet and its main subtypes (i.e., classic ketogenic diet and modified Atkins diet) in adults with intractable epilepsy, and to provide useful information for clinical practice.METHODS:
Electronic searches of PubMed, EMBASE, Google Scholar, and the ISI Web of Science were conducted to identify studies of the efficacy of and patient compliance with a ketogenic diet in adults with intractable epilepsy; the included studies were reviewed. Meta-analyses were performed using STATA to determine combined efficacy rates and combined rates of compliance with the ketogenic diet and its main subtypes.RESULTS:
In total, 12 studies qualified for inclusion, and data from 270 patients were evaluated.The results of the meta-analysis revealed combined efficacy rates of all types of ketogenic diet, a classical ketogenic diet, and a modified Atkins diet were 42%, 52%, and 34%, respectively; the corresponding combined compliance rates were 45%, 38%, and 56%.CONCLUSIONS:
The results indicate that a ketogenic diet is a promising complementary therapy in adult intractable epilepsy, and that while a classical ketogenic diet may be more effective, adult patients are likely to be less compliant with it than with a modified Atkins diet.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Patient Compliance
/
Compliance
/
Epilepsy
/
Diet, Carbohydrate-Restricted
/
Diet, Ketogenic
Type of study:
Prognostic study
/
Systematic reviews
Limits:
Adult
/
Humans
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2015
Type:
Article
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