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Vitrectomy Combined with Intravitreal Triamcinolone Acetonide Injection and Macular Laser Photocoagulation for Nontractional Diabetic Macular Edema
Korean Journal of Ophthalmology ; : 186-193, 2013.
Article in English | WPRIM | ID: wpr-150556
ABSTRACT

PURPOSE:

To evaluate the efficacy of vitrectomy combined with intravitreal injection of triamcinolone acetonide (IVTA) and macular laser photocoagulation for the treatment of nontractional diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (VEGF) therapy.

METHODS:

Twenty-eight eyes from 28 subjects who were diagnosed with nontractional DME refractory to three or more sequential anti-VEGF injections underwent sequential vitrectomy, IVTA, and macular laser photocoagulation. Changes in best-corrected visual acuity (BCVA) and central subfield thickness (CST) during the six months following vitrectomy were evaluated. Additionally, the CST and BCVA outcomes were compared with those of 26 eyes treated with the same triple therapy for nontractional DME refractory to conventional treatment, such as IVTA or macular laser photocoagulation, or both.

RESULTS:

The mean logarithm of the minimum angle of resolution BCVAs before and one, three, and six months after vitrectomy were 0.44 +/- 0.15, 0.36 +/- 0.18, 0.31 +/- 0.14, and 0.34 +/- 0.22, respectively. The mean CSTs were 433.3 +/- 77.9, 329.9 +/- 59.4, 307.2 +/- 60.2, and 310.1 +/- 80.1 microns, respectively. The values of both BCVA and CST at one, three, and six months were significantly improved from baseline (p < 0.05). The extent of CST reduction during the first month after triple therapy was greater in eyes refractory to conventional treatment than in eyes refractory to anti-VEGF (p = 0.012).

CONCLUSIONS:

Vitrectomy combined with IVTA and macular laser photocoagulation had a beneficial effect on both anatomical and functional outcomes in eyes with nontractional DME refractory to anti-VEGF therapy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Vitrectomy / Triamcinolone Acetonide / Macular Edema / Retrospective Studies / Combined Modality Therapy / Diabetic Retinopathy / Intravitreal Injections / Immunosuppressive Agents / Light Coagulation / Macula Lutea Type of study: Observational study Limits: Aged / Female / Humans / Male Language: English Journal: Korean Journal of Ophthalmology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Vitrectomy / Triamcinolone Acetonide / Macular Edema / Retrospective Studies / Combined Modality Therapy / Diabetic Retinopathy / Intravitreal Injections / Immunosuppressive Agents / Light Coagulation / Macula Lutea Type of study: Observational study Limits: Aged / Female / Humans / Male Language: English Journal: Korean Journal of Ophthalmology Year: 2013 Type: Article