Clinical and cytogenetic analysis of midtrimester amniocentesis / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
;
: 365-373, 2006.
Article
in Korean
| WPRIM
| ID: wpr-150836
ABSTRACT
OBJECTIVE:
To analyze clinical data based on prenatal genetic amniocentesis.METHODS:
We analyzed retrospectively maternal age, gestational age, indications, cytogenetic results and complications, based on a total of 496 cases of midtrimester prenatal genetic amniocentesis performed at Sungkyunkwan University School of Medicine, Kangbuk Samsung hospital from March 2000 to May 2005.RESULTS:
The most common age of total subjects was between 35-39 years (37.1%). The indications of amniocentesis were abnormal maternal serum marker (39.72%), advanced maternal age (35.89%), abnormal ultrasonographic finding (5.04%), combined old age and abnormal maternal serum marker (4.23%), in order. Since 2000, the number of amniocentesis due to abnormal ultrasonographic finding was increased. The overall incidence of chromosomal abnormalities were 6.05% (30/496). There was no significant difference between maternal age and abnormal fetal karyotype. According to indications, there was 7.11% (14/197) of chromosomal abnormalities in abnormal maternal serum screening group, 1.69% (3/178) in advanced maternal age group and 22.22% (6/27) in abnormal ultrasonographic finding group.CONCLUSION:
Abnormal maternal serum marker and advanced maternal age were the most common indication. There were frequent chromosomal abnormalities in combined old age and abnormal maternal serum marker group and abnormal ultrasonographic finding group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pregnancy Trimester, Second
/
Biomarkers
/
Mass Screening
/
Incidence
/
Retrospective Studies
/
Chromosome Aberrations
/
Gestational Age
/
Maternal Age
/
Cytogenetic Analysis
/
Cytogenetics
Type of study:
Incidence study
/
Observational study
/
Prognostic study
/
Screening study
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Obstetrics and Gynecology
Year:
2006
Type:
Article
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