Effect of intraperitoneal injection of single chemotherapeutic agent on rat bladder carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine / 대한비뇨기과학회지
Korean Journal of Urology
;
: 177-183, 1991.
Article
in Korean
| WPRIM
| ID: wpr-150961
ABSTRACT
Chemotherapeutic agents were evaluated for their effect on the development of urinary bladder tumors, induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in female Sprague-Dawley rats. For 16 weeks, 0.05% BBN was administered orally, and then chemotherapeutic agents (adriamycin and cisplatin) were injected intraperitoneally for 12 weeks. In our preliminary experimental series, an experimental bladder tumor model induced by BBN was useful in evaluating the effectiveness of chemotherapeutic agents. Cisplatin appears to be effective in inhibiting precancerous histologic changes and carcinoma in rat urinary bladder mucosa by BBN. However, the effectiveness of adriamycin was inconclusive.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urinary Bladder
/
Urinary Bladder Neoplasms
/
Doxorubicin
/
Cisplatin
/
Rats, Sprague-Dawley
/
Carcinogenesis
/
Injections, Intraperitoneal
/
Mucous Membrane
Limits:
Animals
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
1991
Type:
Article
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