Antinociceptive Effects of the Essential Oil of Ocimum Basilicum in Mice
The Korean Journal of Pain
;
: 206-209, 2009.
Article
in Korean
| WPRIM
| ID: wpr-151017
ABSTRACT
BACKGROUND:
The essential oil of Ocimum basilicum (EOOB) has a pleasant aroma and is known to have antimicrobial and insecticidal activities. In addition, it is used as a pain reliever in folk medicine. However, there are few reports on the antinociceptive activities of EOOB.METHODS:
This study examined the antinociceptive effects of EOOB using formalin and a plantar test in mice. In the formalin test, EOOB (50 mg/kg, 100 mg/kg, 150 mg/kg) was administered intraperitoneally and the licking time of the mice was measured. In the plantar test, intraperitoneal EOOB (50 mg/kg, 100 mg/kg) was administered and the withdrawal latency was measured using the Hargreaves method.RESULTS:
In the formalin test, EOOB (50 mg/kg, IP) showed significant decreases in licking time in the second phase. On the other hand, in the plantar test, there were no significant effects in any of the groups examined.CONCLUSIONS:
These results support the traditional use of EOOB for the treatment of painful conditions. However, there is a need for more research to determine the active chemical constituents and the precise mechanism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pain Measurement
/
Ocimum basilicum
/
Ocimum
/
Formaldehyde
/
Hand
/
Medicine, Traditional
Limits:
Animals
Language:
Korean
Journal:
The Korean Journal of Pain
Year:
2009
Type:
Article
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