Outer Blood-retinal Barrier Alteration Induced by Intraocular Ad vanced Glycation Endproduct
Journal of the Korean Ophthalmological Society
;
: 373-377, 2001.
Article
in Korean
| WPRIM
| ID: wpr-151065
ABSTRACT
Advanced glycation end-product(AGE)is known as a factor causing diabetic retinopathy, but little is known about its effect on the function of outer blood-retinal barrier. To test whether AGE can increase the permeability of outer blood-retinal barrier, we injected glycated albumin into white rabbit eyes and observed the change of the fundus and of the outer blood-retinal barrier permeability. The rabbit retina in medullary ray was thickened in AGE-injected eyes. Intravenously injected microperoxidase, tracer molecule, was found in outer sensory retinal layer and outside of the retinal pigment epithelium in AGE-injected eyes. These results suggest that intraocularly injected AGE can increase the outer blood-retinal barrier permeability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Retina
/
Retinaldehyde
/
Blood-Retinal Barrier
/
Diabetic Retinopathy
/
Retinal Pigment Epithelium
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2001
Type:
Article
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