Reduced Fertility and Fecundity among Patients with Bipolar I Disorder and Schizophrenia in Egypt
Psychiatry Investigation
;
: 214-220, 2011.
Article
in English
| WPRIM
| ID: wpr-151082
ABSTRACT
OBJECTIVE:
To evaluate reproduction among patients with bipolar I disorder (BP1) or schizophrenia (SZ) in Egypt.METHODS:
BP1 patients (n=113) were compared with community based, demographically balanced controls (n=124) and SZ patients (n=79, DSM-IV). All participants were evaluated using structured interviews and corroborative data were obtained from relatives. Standard indices of procreation were included in multivariate analyses that incorporated key demographic variables.RESULTS:
Control individuals were significantly more likely to have children than BP1 or SZ patients (controls 46.8%, BP1 15.9%, SZ 17.7%), but the BP1-SZ differences were non-significant. The average number of children for BP1 patients (0.37+/-0.9) and SZ patients (0.38+/-0.9) was significantly lower than for controls (1.04+/-1.48) (BP1 vs controls, p<0.001; SZ vs controls, p<0.001). The frequency of marriages among BP1 patients was nominally higher than the SZ group, but was significantly lower than controls (BP1 31.9% SZ 27.8% control 57.3%). Even among married individuals, BP1 (but not SZ) patients were childless more often than controls (p=0.001). The marital fertility, i.e., the average number of children among patients with conjugal relationships for controls (1.8+/-1.57) was significantly higher than BP1 patients (1.14+/-1.31, p=0.02), but not significantly different from SZ patients (1.36+/-1.32, p=0.2).CONCLUSION:
Selected reproductive measures are significantly and substantially reduced among Egyptian BP1 patients. The reproductive indices are similar among BP1 and SZ patients, suggesting a role for general illness related variables. Regardless of the cause/s, the impairment constitutes important, under-investigated disability.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reproduction
/
Schizophrenia
/
Bipolar Disorder
/
Marriage
/
Multivariate Analysis
/
Egypt
/
Fertility
Type of study:
Prognostic study
/
Qualitative research
Limits:
Child
/
Humans
Country/Region as subject:
Africa
Language:
English
Journal:
Psychiatry Investigation
Year:
2011
Type:
Article
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