The role of squamous cell carcinoma antigen as a prognostic and predictive factor in carcinoma of uterine cervix
Radiation Oncology Journal
;
: 191-198, 2011.
Article
in English
| WPRIM
| ID: wpr-151091
ABSTRACT
PURPOSE:
Although the role of squamous cell carcinoma antigen (SCC-Ag) as a predictive and prognostic factor for uterine cervical cancer has been identified in previous studies, 1) the effective patient group of screening for recurrence with SCC-Ag, 2) the relationship between SCC-Ag and recurrence site, and 3) the relationship between the change of SCC-Ag and treatment outcome or recurrence have not been described. MATERIALS ANDMETHODS:
The study included 506 patients with histologically proven uterine cervical cancer between January 1994 and December 2010. We determining the serum SCC-Ag level before treatment and after treatment, and conducted a retrospective review of the patients' records. We evaluated the sensitivity and specificity of SCC-Ag for the detection of tumor recurrence by comparing biochemical recurrence with clinical recurrence.RESULTS:
The pretreatment SCC-Ag level and the proportion of patients over 1.5 ng/mL were higher in poor prognostic patient group. In the univariate and multivariate analysis, pretreatment SCC-Ag showed a statistically significant correlation with tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage, pathology. In patients with biochemical recurrence vs. those without, 5-year DFS and OS were 27.6 vs. 92.7% (p < or = 0.001) and 53.7 vs. 92.5% (p < or = 0.001), respectively.CONCLUSION:
Our study reconfirmed the known function of pretreatment SCC-Ag, but could not confirm the function of biochemical response as a predictive factor for treatment and as a prognostic factor. There was no statistically significant relationship between SCC-Ag level and recurrence site. We confirmed the role of SCC-Ag as a follow-up tool for recurrence of disease and which patient groups SCC-Ag was more useful for.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Carcinoma, Squamous Cell
/
Serpins
/
Uterine Cervical Neoplasms
/
Cervix Uteri
/
Mass Screening
/
Multivariate Analysis
/
Retrospective Studies
/
Follow-Up Studies
/
Sensitivity and Specificity
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
/
Screening study
Limits:
Female
/
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS