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A case of peripheral T-cell lymphoma with central nervous system and bilateral pulmonary involvement / 대한내과학회지
Korean Journal of Medicine ; : 643-648, 2009.
Article in Korean | WPRIM | ID: wpr-151169
ABSTRACT
Mature T-cell non-Hodgkin's lymphoma (NHL) has more frequent extranodal involvement and is less sensitive to chemotherapy than B-cell lymphoma. Peripheral T-cell lymphoma unspecified (PTCL-U) is rarely combined with pulmonary or CNS involvement. We report a case of PTCL-U with lung and CNS involvement that was treated with high-dose chemotherapy followed by autologous stem cell transplantation (ASCT). A 62-year-old man was admitted with right-side weakness and paresthesias, and was diagnosed with PTCL-U after alung biopsy. Successful complete remission was achieved after threecycles of IMEP (ifosfamide, methotrexate, etoposide, and prednisone) chemotherapywith concurrent intrathecal chemotherapy and subsequent high-dose chemotherapy with ASCT to treat potential advanced stage PTCL-U. The non-anthracycline-containing IMEP regimen can be effective for PTCL-U, especially in cases with CNS involvement.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Paresthesia / Biopsy / Lymphoma, Non-Hodgkin / T-Lymphocytes / Central Nervous System / Methotrexate / Lymphoma, B-Cell / Lymphoma, T-Cell, Peripheral / Stem Cell Transplantation / Etoposide Limits: Humans Language: Korean Journal: Korean Journal of Medicine Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Paresthesia / Biopsy / Lymphoma, Non-Hodgkin / T-Lymphocytes / Central Nervous System / Methotrexate / Lymphoma, B-Cell / Lymphoma, T-Cell, Peripheral / Stem Cell Transplantation / Etoposide Limits: Humans Language: Korean Journal: Korean Journal of Medicine Year: 2009 Type: Article