Prevalence of alpha1-Antitrypsin Genotypes in Koreans / 결핵
Tuberculosis and Respiratory Diseases
;
: 229-235, 2001.
Article
in Korean
| WPRIM
| ID: wpr-15129
ABSTRACT
BACKGROUND:
Alpha-1-antitrypsin (A1AT) deficiency is the only established genetic resk factor for emphysema. This study was undertaken to investigate the prevalence of the genotypes of A1AT genotypes in healthy Koreans.METHOD:
The study population consisted of 380 healthy Koreans enrolled at the Health Promotion Center in Kyungpook National University Hospital. The polymerase chain reaction (PCR) and restriction fragment length polymorphim (RFLP) for detecting the A1AT variants M1(Ala), M1(Val), M2, S and Z were used.RESULTS:
The genotypes of subjects were as follows M1(Val)/M1(Val), 254(66.8%) ; M1(Val)/M2, 105(27.6%) ; M2/M2, 19 (5.0%) ; and M1(Val)/M1(Ala), 2 (0.5%). There was no case with 'deficiency' alleles such as S and Z found in this study.CONCLUSION:
These results suggest that A1AT deficient alleles are either extremely rare or not present in Koreans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymerase Chain Reaction
/
Prevalence
/
Emphysema
/
Alleles
/
Genotype
/
Health Promotion
Type of study:
Prevalence study
/
Risk factors
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2001
Type:
Article
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