Association of the CYP1B1 Gene Polymorphism with the Risk of Advanced Endometriosis in Korean Women / 대한불임학회지
Korean Journal of Fertility and Sterility
;
: 85-95, 2006.
Article
in Korean
| WPRIM
| ID: wpr-151311
ABSTRACT
OBJECTIVE:
To investigate whether polymorphisms of gene encoding CYP1B1 is associated with the risk of endometriosis in Korean women.METHODS:
We investigated 199 patients with histopathologically confirmed endometriosis rAFS stage III/IV and 183 control group women who were surgically proven to have no endometriosis. The genetic distribution of four different CYP1B1 polymorphisms at G119-T, G432-C, T449-C, and A453-G were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism of PCR products.RESULTS:
We found no overall association between each individual CYP1B1 genotype and the risk of endometriosis. The odds ratio of genotype GG/GC+GG/TC+TT/AA compared to GG/CC/CC/AA (reference) was calculated as 2.06 with a 95% confidence interval of 1.003~4.216.CONCLUSIONS:
This results suggest that CYP1B1 genetic polymorphism may be associated with development of endometriosis in Korean women.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Polymorphism, Restriction Fragment Length
/
Odds Ratio
/
Polymerase Chain Reaction
/
Endometriosis
/
Genotype
Type of study:
Etiology study
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Fertility and Sterility
Year:
2006
Type:
Article
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