Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice
Biomolecules & Therapeutics
;
: 249-258, 2017.
Article
in English
| WPRIM
| ID: wpr-151382
ABSTRACT
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naïve mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-ζ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-ζ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Kinases
/
Water
/
Blotting, Western
/
Dizocilpine Maleate
/
N-Methylaspartate
/
Cognition
/
Cognition Disorders
/
Syzygium
/
Hippocampus
/
Memory
Limits:
Animals
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2017
Type:
Article
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