Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice
Journal of Veterinary Science
;
: 189-195, 2009.
Article
in English
| WPRIM
| ID: wpr-151427
ABSTRACT
This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p < 0.01). All test solutions significantly decreased the levels of triglyceride, glucose and free fatty acids in the serum compared with control (p < 0.05). The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p < 0.05). CLA significantly decreased weights of renal and epididymal fats compared with the control (p < 0.05). DG and DG-CLA also significantly decreased the epididymal fat weights compared with the control (p < 0.05). A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG, CLA, and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22% CLA have a respectable anti-obesity effect by controlling serum lipids and fat metabolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
Blood Chemical Analysis
/
Body Weight
/
Adipose Tissue
/
Gene Expression Regulation
/
Anti-Obesity Agents
/
Linoleic Acids, Conjugated
/
PPAR gamma
/
Diglycerides
/
Disease Models, Animal
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2009
Type:
Article
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