Immunohistochemical localization of galectin-3 in the granulomatous lesions of paratuberculosis-infected bovine intestine
Journal of Veterinary Science
;
: 177-180, 2009.
Article
in English
| WPRIM
| ID: wpr-151429
ABSTRACT
The presence of galectin-3 was immunohistochemically quantified in bovine intestines infected with paratuberculosis (Johne's disease) to determine whether galectin-3 was involved in the formation of granulation tissue associated with the disease. Mycobacterium avium subsp. paratuberculosis infection was histochemically confirmed using Ziehl-Neelsen staining and molecularly diagnosed through rpoB DNA sequencing. Galectin-3 was detected in the majority of inflammatory cells, possibly macrophages, in the granulomatous lesions within affected tissues, including the ileum. These findings suggest that galectin-3 is associated with the formation of chronic granulation tissues in bovine paratuberculosis, probably through cell adhesion and anti-apoptosis mechanisms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paratuberculosis
/
RNA Polymerase II
/
Immunohistochemistry
/
Cattle Diseases
/
Chronic Disease
/
Galectin 3
/
Intestine, Small
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2009
Type:
Article
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