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Clathrin Assembly Lymphoid Myeloid Leukemia-AF10-positive Acute Leukemias: A Report of 2 Cases with a Review of the Literature / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine ; : 117-121, 2010.
Article in English | WPRIM | ID: wpr-151632
ABSTRACT
The translocation t(10;11)(p13;q14q21) has been found to be recurrent in acute lymphoblastic and myeloid leukemias, and results in the fusion of the clathrin assembly lymphoid myeloid leukemia (CALM) gene with the AF10 gene; these genes are present on chromosomes 11 and 10, respectively. Because the CALM-AF10 rearrangement is a rare chromosomal abnormality, it is not included in routine molecular tests for acute leukemia. Here, we describe the cases of 2 patients with the CALM-AF10 fusion gene. The first patient (case 1) was diagnosed with T-cell ALL, and the second patient (case 2) was diagnosed with AML. Both patient samples showed expression of the homeobox A gene cluster and the histone methyltransferase hDOT1L, which suggests that they mediate leukemic transformation in CALM-AF10-positive and mixed-lineage leukemia-AF10-positive leukemias. Both patients achieved complete remission after induction chemotherapy. The first patient (case 1) relapsed after double-unit cord blood transplantation; there was no evidence of relapse in the second patient (case 2) after allogenic peripheral blood stem cell transplantation. Since CALM-AF10- positive leukemias have been shown to have poor prognosis with conventional therapy, molecular tests for CALM-AF10 rearrangement would be necessary to detect minimal residual disease during follow-up.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Transcription Factors / Translocation, Genetic / Bone Marrow / Chromosomes, Human, Pair 10 / Chromosomes, Human, Pair 11 / Leukemia, Myeloid, Acute / Oncogene Proteins, Fusion / Histone-Lysine N-Methyltransferase / Homeodomain Proteins Type of study: Prognostic study Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: The Korean Journal of Laboratory Medicine Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Recurrence / Transcription Factors / Translocation, Genetic / Bone Marrow / Chromosomes, Human, Pair 10 / Chromosomes, Human, Pair 11 / Leukemia, Myeloid, Acute / Oncogene Proteins, Fusion / Histone-Lysine N-Methyltransferase / Homeodomain Proteins Type of study: Prognostic study Limits: Adolescent / Adult / Female / Humans / Male Language: English Journal: The Korean Journal of Laboratory Medicine Year: 2010 Type: Article