Monocyte Chemoattractant Protein-1(MCP1) -2518 Polymorphism and Bipolar I Disorder / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 524-528, 2004.
Article
in Korean
| WPRIM
| ID: wpr-151640
ABSTRACT
OBJECTIVES:
Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter -2518 and BD.METHODS:
Patients with BD (n=92) in accordance with DSM-IV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method.RESULTS:
Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587; p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups.CONCLUSION:
Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Suicide
/
Bipolar Disorder
/
DNA
/
Monocytes
/
Cytokines
/
Promoter Regions, Genetic
/
Chemokine CCL2
/
Mood Disorders
/
Diagnostic and Statistical Manual of Mental Disorders
/
Alleles
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2004
Type:
Article
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