Glutathione S-Transferase M1 Polymorphism and Schizophrenia / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 519-523, 2004.
Article
in Korean
| WPRIM
| ID: wpr-151641
ABSTRACT
OBJECTIVES:
This study aimed to test the possible association between Glutathione S-Transferase M1 gene (GSTM1) variants and schizophrenia.METHODS:
One hundred and eleven inpatients with schizophrenia and 130 healthy controls were recruited. Genotyping was performed by polymerase chain reaction-based method.RESULTS:
The GSTM1 null genotype was significantly more frequent in patients with schizophrenia than in controls (p=0.014, odd ratio=1.93, 95% confidence interval=1.115-3.351), while GSTM1 genotype variants were not associated with either tardive dyskinesia (TD) or total Abnormal Involuntary Movement Scale (AIMS) scores.CONCLUSION:
The present study suggests that the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to TD, at least in Korean population.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia
/
Dyskinesias
/
Genotype
/
Glutathione
/
Glutathione Transferase
/
Inpatients
/
Movement Disorders
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2004
Type:
Article
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