The Usefulness of the UBC(TM)(Urinary Bladder Cancer) Test for Screening of Transitional Cell Carcinoma of the Bladder in Patients with Hematuria / 대한비뇨기과학회지
Korean Journal of Urology
;
: 14-18, 2004.
Article
in Korean
| WPRIM
| ID: wpr-151797
ABSTRACT
PURPOSE:
A new quantitative tumor marker, based on the combined measurement of urinary fragments of cytokeratins 8 and 18, namely the urinary bladder cancer antigen(UBC(TM)) test, has been proposed for the detection of bladder transitional cell carcinoma(TCC). We evaluated the diagnostic efficacy of UBC(TM) test in comparison with that of urinary cytology to establish UBC(TM) test for the diagnosis of TCC. MATERIALS ANDMETHODS:
One-hundred ninety-six patients with hematuria were included in this study. Forty patients were diagnosed histologically as TCC by transurethral resection or radical cystectomy(group A), while the others had various benign urinary tract conditions(group B).RESULTS:
UBC(TM) levels were significantly different between groups A (1851.39+/-4627microgram/l) and B (19.28+/-107.03microgram/l) (p<0.001). Sensitivity for diagnosis of TCC was 89.7%(36/40) in UBC(TM) test and 45%(18/40) in cytology(p<0.05). Specificity for diagnosis of TCC was 84.6%(132/156) in UBC(TM) test and 100%(156/156) in cytology. UBC(TM) test was significantly more sensitive than cytology in stage Ta(85.7% vs. 0%, p<0.05), T1 tumors(89.4% vs. 31.5%, p<0.05), and in Grades 1(83.3% vs. 25%, p<0.05) and 2(90.4% vs. 52.3%, p<0.05) tumors. UBC(TM) test was more sensitive in higher Grade(83.3% in Grade 1, 90.4% in Grade 2 and 100% in Grade 3).CONCLUSIONS:
In comparison with urinary cytology, UBC(TM) test could be a valuable marker for diagnosis of TCC in patients with early stage and low grade TCC. Therefore, UBC(TM) test in association with cytology may be useful as a screening test for TCC of the bladder.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Urinary Tract
/
Urinary Bladder
/
Urinary Bladder Neoplasms
/
Carcinoma, Transitional Cell
/
Mass Screening
/
Sensitivity and Specificity
/
Diagnosis
/
Hematuria
/
Keratins
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2004
Type:
Article
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