A Case of Hereditary Spherocytosis Coexisting with Gilbert's Syndrome / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 166-169, 2013.
Article
in English
| WPRIM
| ID: wpr-152218
ABSTRACT
We recently encountered a case of hereditary spherocytosis coexisting with Gilbert's syndrome. Patient was initially diagnosed with Gilbert's syndrome and observed, but other findings suggestive of concurrent hemolysis, such as splenomegaly and gallstones were noted during the follow-up period. Therefore, further evaluations, including a peripheral blood smear, osmotic fragility test, autohemolysis test, and red blood cell membrane protein test were performed, and coexisting hereditary spherocytosis was diagnosed. Genotyping of the conjugation enzyme uridine diphosphate-glucuronosyltransferase was used to confirm Gilbert's syndrome. Because of the high prevalence rates and similar symptoms of these 2 diseases, hereditary spherocytosis can be masked in patients with Gilbert's syndrome. In review of a case and other article, the possibility of the coexistence of these 2 diseases should be considered, especially in patients with unconjugated hyperbilirubinemia who also have splenomegaly and gallstones.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spherocytosis, Hereditary
/
Splenomegaly
/
Gallstones
/
Glucuronosyltransferase
/
Polymorphism, Single Nucleotide
/
Erythrocytes
/
Genotype
/
Gilbert Disease
/
Hemolysis
/
Hyperbilirubinemia
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Gastroenterology
Year:
2013
Type:
Article
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