In Vitro Coagulation Study of Hemodiluted Blood with Hydroxyethyl Starch by Thromboelastography / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 800-804, 2000.
Article
in Korean
| WPRIM
| ID: wpr-152255
ABSTRACT
BACKGROUND:
To avoid the risks associated with transfusion of homologous blood products, artificial colloid solutions represent an alternative for intra-operative blood loss replacement. However, synthetic colloids have been implicated as a cause of coagulopathy when administered in large quantities. We investigated the effect of Hydroxyethyl starch (HES) on blood coagulation in vitro under thromboelastography (TEG).METHODS:
Whole blood was withdrawn from fifteen volunteers undergoing peripheral surgery who had no history of coagulation defect. Whole blood was diluted with HES to 25, 50 and 75 vol% concentrations, and the changes in coagulation status were analysed using TEG and were compared with those of an undiluted control specimen obtained concurrently from the same patients.RESULTS:
Hemodilution with HES solution at 50 vol% concentration decreased the MA and alpha angle values (P < 0.05), but the R and K values remained unchanged. In case of profound hemodilution at a 75 vol% concentration, the values of MA and alpha angle were severely decreased (P < 0.05) and the values of R and K were severely increased (P < 0.05).CONCLUSIONS:
There were many reports that moderate hemodilution with crystalloids increased coagulability, but hemodilutions up to 50 vol% concentration with HES solution did not significantly change blood coagulability. Significant hypocoagulability occurred at a 75 vol% hemodilution with HES.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Starch
/
Thrombelastography
/
Volunteers
/
Blood Coagulation
/
Colloids
/
Hemodilution
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2000
Type:
Article
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