Interhemispheric Modulation of Dual-Mode, Noninvasive Brain Stimulation on Motor Function
Annals of Rehabilitation Medicine
;
: 297-303, 2014.
Article
in English
| WPRIM
| ID: wpr-152264
ABSTRACT
OBJECTIVE:
To investigate the effects of simultaneous, bihemispheric, dual-mode stimulation using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) on motor functions and cortical excitability in healthy individuals.METHODS:
Twenty-five healthy, right-handed volunteers (10 men, 15 women; mean age, 25.5 years) were enrolled. All participants received four randomly arranged, dual-mode, simultaneous stimulations under the following conditions condition 1, high-frequency rTMS over the right primary motor cortex (M1) and sham tDCS over the left M1; condition 2, high-frequency rTMS over the right M1 and anodal tDCS over the left M1; condition 3, high-frequency rTMS over the right M1 and cathodal tDCS over the left M1; and condition 4, sham rTMS and sham tDCS. The cortical excitability of the right M1 and motor functions of the left hand were assessed before and after each simulation.RESULTS:
Motor evoked potential (MEP) amplitudes after stimulation were significantly higher than before stimulation, under the conditions 1 and 2. The MEP amplitude in condition 2 was higher than both conditions 3 and 4, while the MEP amplitude in condition 1 was higher than condition 4. The results of the Purdue Pegboard test and the box and block test showed significant improvement in conditions 1 and 2 after stimulation.CONCLUSION:
Simultaneous stimulation by anodal tDCS over the left M1 with high-frequency rTMS over the right M1 could produce interhemispheric modulation and homeostatic plasticity, which resulted in modulation of cortical excitability and motor functions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plastics
/
Volunteers
/
Brain
/
Evoked Potentials, Motor
/
Transcranial Magnetic Stimulation
/
Hand
/
Motor Cortex
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Annals of Rehabilitation Medicine
Year:
2014
Type:
Article
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