Relationship between 15-hydroxyprostaglandin dehydrogenase and gastric adenocarcinoma
Annals of Surgical Treatment and Research
;
: 302-308, 2014.
Article
in English
| WPRIM
| ID: wpr-152271
ABSTRACT
PURPOSE:
Prostaglandin E2 (PGE2) is a contributory carcinogen in gastric adenocarcinoma. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) catabolizes PGE2 by oxidizing its 15(s)-hydroxy group. The aim of this study was to investigate the expression of 15-PGDH in gastric adenocarcinoma tissue and the relationship between 15-PGDH expression and clinicopathologic features of gastric adenocarcinoma.METHODS:
Ninety-nine patients who underwent surgical resection for gastric adenocarcinoma between January 2007 and December 2007 were enrolled and evaluated retrospectively.RESULTS:
In 62 patients (62.6%), 15-PGDH expression was lower in gastric adenocarcinoma tissue than in nonneoplastic tissue. Regarding the relationship between 15-PGDH expression and clinicopathological features, 15-PGDH expression was significantly lower in tissues with poor differentiation (P = 0.002), advanced T stage (P = 0.0319), a higher number of lymph node metastases (P = 0.045), lymphatic invasion (P = 0.031), and vascular invasion (P = 0.036).CONCLUSION:
15-PGDH expression was associated with a subset of clinicopathologic features such as differentiation grade, T stage, lymphatic invasion, and vascular invasion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxidoreductases
/
Stomach Neoplasms
/
Dinoprostone
/
Adenocarcinoma
/
Retrospective Studies
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS