A Case of Acute Promyelocytic Leukemia with a De novo t(11;19) Chromosomal Translocation / 대한내과학회지
Korean Journal of Medicine
;
: S268-S272, 2011.
Article
in Korean
| WPRIM
| ID: wpr-152515
ABSTRACT
Acute promyelocytic leukemia (APL), which is usually defined by the morphological features of the leukemic cells, is characterized by the t(15;17) (q22;q21) chromosomal translocation and disseminated intravascular coagulation. This specific translocation results in a new fusion transcript between the promyelocytic leukemia (PML) gene and the retinoic acid receptor-alpha (RARalpha) gene. Although the presence of this fusion gene can predict a favorable clinical response to all-trans-retinoic-acid (ATRA) treatment, APL with chromosomal translocations other than t(15;17) (q22;q21) is extremely rare and is associated with a poor prognosis. We experienced a case of APL with de novo t(11;19).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Translocation, Genetic
/
Tretinoin
/
Leukemia, Promyelocytic, Acute
/
Leukemia
/
Disseminated Intravascular Coagulation
/
Pathology, Molecular
Type of study:
Diagnostic study
/
Prognostic study
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2011
Type:
Article
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