A Rare Case of Microgranular Acute Promyelocytic Leukemia Associated with ider(17)(q10)t(15;17) in an Old-age Patient / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 86-90, 2011.
Article
in English
| WPRIM
| ID: wpr-152848
ABSTRACT
We present a rare case of microgranular variant acute promyelocytic leukemia (APL) associated with ider(17)(q10)t(15;17)(q22;q12) of an old-age patient. The initial chromosome study showed a 46,XX,del(6)(?q21q25),der(15)t(15;17)(q22;q12),ider(17)(q10)t(15;17)[10]/47,sl,+ider(17)(q10)t(15;17)[3]/46,XX[16]. FISH signals from a dual color dual fusion translocation PML-RARA probe were consistent with the results of conventional cytogenetics. Because of the rarity of ider(17)(q10)t(15;17) in microgranular APL, further studies on both gene dosage effect of this chromosomal abnormality and the influence of ider(17)(q10)t(15;17) on clinical features such as prognosis, survival, and treatment response of APL cases are recommended.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Translocation, Genetic
/
Chromosomes, Human, Pair 15
/
Chromosomes, Human, Pair 17
/
Bone Marrow Cells
/
Leukemia, Promyelocytic, Acute
/
Oncogene Proteins, Fusion
/
In Situ Hybridization, Fluorescence
/
Karyotyping
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
The Korean Journal of Laboratory Medicine
Year:
2011
Type:
Article
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