Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
Clinical Psychopharmacology and Neuroscience
;
: 269-275, 2017.
Article
in English
| WPRIM
| ID: wpr-152979
ABSTRACT
OBJECTIVE:
Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD.METHODS:
Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA.RESULTS:
Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls.CONCLUSION:
These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Bipolar Disorder
/
Enzyme-Linked Immunosorbent Assay
/
Comorbidity
/
Tumor Necrosis Factor-alpha
/
Apoptosis
/
Receptors, Tumor Necrosis Factor
/
Depression
/
TNF-Related Apoptosis-Inducing Ligand
/
Inflammation
Limits:
Humans
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2017
Type:
Article
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