Improvement of Visuo-spatial Function Assessed by Raven’s Colored Progressive Matrices in Dementia with Lewy Bodies by Donepezil Treatment
Clinical Psychopharmacology and Neuroscience
;
: 243-247, 2017.
Article
in English
| WPRIM
| ID: wpr-152983
ABSTRACT
OBJECTIVE:
Donepezil is used to improve cognitive impairment of dementia with Lewy bodies (DLB). Visuo-spatial dysfunction is a well-known symptom of DLB. Non-verbal Raven’s Colored Progressive Matrices (RCPM) were used to assess both visual perception and reasoning ability in DLB subjects treated with donepezil.METHODS:
Twenty-one DLB patients (mean age, 78.7±4.5 years) were enrolled. RCPM assessment was performed at the time of starting donepezil and within one year after starting donepezil.RESULTS:
There were significant improvements of RCPM in the total scores between one year donepezil treatment (p=0.013), in both Set A score (p=0.002) and Set AB score (p=0.015), but trend in the Set B score (p=0.083).CONCLUSION:
Donepezil is useful for improving visuo-spatial impairment in DLB, but not for problem-solving impairment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Visual Perception
/
Cholinesterase Inhibitors
/
Lewy Bodies
/
Cognition Disorders
/
Lewy Body Disease
/
Dementia
/
Spatial Processing
Limits:
Humans
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2017
Type:
Article
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