Diagnostic Accuracy and Detection Rate of Real-Time PCR for Detection of Group B Streptococcal Colonization in Pregnant Women: Systemic Review of Literature and Meta-Analysis / 대한임상미생물학회지
Annals of Clinical Microbiology
;
: 42-51, 2017.
Article
in Korean
| WPRIM
| ID: wpr-153458
ABSTRACT
BACKGROUND:
Group B streptococcus (Streptococcus agalactiae, GBS) was reported as a major cause of neonatal infection and death. To prevent vertical transmission, CDC recommended that all women in week 35-37 of pregnancy should receive the GBS colonization test. We conducted a systematic review and meta-analysis to evaluate diagnostic accuracy and detection rate of real-time PCR for GBS in pregnant women.METHODS:
The literature review for GBS using real-time PCR was done including KoreaMed, Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library on November 3, 2015. 443 articles were collected. Two authors select articles and evaluated the quality of studies using Scottish Intercollegiate Guidelines Network tool independently.RESULTS:
Diagnostic accuracy of the real-time PCR was assessed by meta-analysis through 34 articles (13,516 for real-time PCR, 1,815 for culture and other comparison test). The GBS colonization was assessed through 34 articles, which reported varying values of 2.0–69.2% using real-time PCR. The real-time PCR for GBS was shown to have overall sensitivity of 0.93 (95% CI 0.92–0.94, I2=86.3%), overall specificity of 0.96 (95% CI 0.96–0.96, I2=90.2%), SROC AUC of 0.99.CONCLUSION:
Real-time PCR is an effective test for detecting GBS colonization in pregnant women, resulted in preventing the infection in a new born baby.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Streptococcus
/
Streptococcus agalactiae
/
Sensitivity and Specificity
/
Colon
/
Area Under Curve
/
Pregnant Women
/
Real-Time Polymerase Chain Reaction
Type of study:
Diagnostic study
/
Practice guideline
/
Prognostic study
/
Systematic reviews
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Annals of Clinical Microbiology
Year:
2017
Type:
Article
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