Cellular components of proliferative vitreoretinal membranes
Korean Journal of Ophthalmology
;
: 68-75, 1991.
Article
in English
| WPRIM
| ID: wpr-153514
ABSTRACT
To understand the pathogenesis of proliferative vitreoretinal membrane formation which occurs in proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR), etc., accurate identification of the cellular components of the membrane is needed. This study was performed to identify cellular components of the membranes by means of immunohistochemical technique. 11 proliferative vitreoretinal membranes which were surgically obtained from 7 eyes with PVR and 4 eyes with PDR were stained with monoclonal antibodies against cytokeratin, glial fibrillary acidic protein (GFAP), or vimentin using immunoperoxidase technique (ABC method). In the PVR membranes, mean cell positivities for cytokeratin, GFAP and vimentin were 48%, 1% and 92%, respectively and in the PDR membranes, 0%, 5% and 93%, respectively. The above results suggest that retinal pigment epithelial cells and fibroblasts are major cellular components of PVR membranes, and that mesenchymal cells are major cellular components and glial cells are minor cellular components of PDR membranes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retinal Diseases
/
Vitreous Body
/
Cell Membrane
/
Immunoenzyme Techniques
/
Diabetic Retinopathy
/
Eye Diseases
/
Intermediate Filament Proteins
/
Antibodies, Monoclonal
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
1991
Type:
Article
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