A Case of Severe Bevacizumab-induced Ischemic Pancolitis, Treated with Conservative Management / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 42-46, 2011.
Article
in Korean
| WPRIM
| ID: wpr-153659
ABSTRACT
Bevacizumab (Avastin(R)) is a monoclonal antibody against the vascular endothelial growth factor (VEGF) receptor that increases the overall survival rate when added to standard chemotherapy regimens in patients with metastatic colorectal cancer. The known toxicities of bevacizumab are hypertension, proteinuria, wound healing complications, arterial thrombosis, bleeding, and gastrointestinal complications. Especially ischemic colitis can rapidly develop into bowel perforation, so an emergency operation often is needed. Recently, a 65-year-old male patient developed ischemic pancolitis after FOLFOX (85 mg/m2 Oxaliplatin, d1;200 mg/m2 Leucovorin, d1;400 mg/m2 5-FU iv bolus, d1-2;and 600 mg/m2 5-FU, d1-2, every two wk) and Bevacizumab combination chemotherapy was administered. However, he recovered after early conservative care without surgery. We report this case with a review of literature.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organoplatinum Compounds
/
Drug Administration Schedule
/
Colorectal Neoplasms
/
Antineoplastic Combined Chemotherapy Protocols
/
Tomography, X-Ray Computed
/
Leucovorin
/
Colitis, Ischemic
/
Antibodies, Monoclonal, Humanized
/
Fluorouracil
/
Intubation, Gastrointestinal
Limits:
Aged
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2011
Type:
Article
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