The Effects of Etodolac, Nimesulid and Naproxen Sodium on the Frequency of Sister Chromatid Exchange after Enclused Third Molars Surgery
Yonsei Medical Journal
;
: 742-747, 2008.
Article
in English
| WPRIM
| ID: wpr-153703
ABSTRACT
PURPOSE:
Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures in dentistry. The evaluation of the frequency of sister chromatid exchange (SCE) is accepted as a reliable cytogenetic method to assess the genotoxic effects of environmental factors. MATERIALS ANDMETHODS:
In this study, the genotoxic effects of various NSAIDs were assessed in 30 patients to who they were administered following encluosed third molar surgery using SCE analysis before and after the operation. The frequency of SCE was evaluated before the operation and after 3 days of etodolac, nimesulid and naproxen use.RESULTS:
There was no statistically significant difference in the frequency of SCE between the preoperative and postoperative states in patients given etodolac, nimesulid or naproxen sodium.CONCLUSION:
Short term use of selective and non-selective NSAIDs was not associated with a significant genotoxic effect that could be detected using the SCE method in peripheric lymphocytes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sister Chromatid Exchange
/
Sulfonamides
/
Anti-Inflammatory Agents, Non-Steroidal
/
Naproxen
/
Prospective Studies
/
Etodolac
/
Molar, Third
/
Mutagenicity Tests
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2008
Type:
Article
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