Maternal and Neonatal Effects of Substance Abuse during Pregnancy: Our Ten-year Experience
Yonsei Medical Journal
;
: 705-713, 2008.
Article
in English
| WPRIM
| ID: wpr-153708
ABSTRACT
PURPOSE:
The aim of the study was to assess perinatal outcome of pregnancy burdened with maternal addiction in comparison with an unselected population from a European transition country. MATERIALS ANDMETHODS:
Data on pregnancies complicated by illicit drug abuse (n = 85) managed during a 10-year period (1997-2007) at Split University Hospital were analyzed. Data on the type of drug, course of gestation and labor, and on perinatal outcome were considered. Data on all non-dependence pregnancies recorded during the study period were used as a control group.RESULTS:
During the study period, there were 85 dependence-complicated pregnancies (0.2%). Use of heroin alone during pregnancy was recorded in 51 women (50%), methadone alone in 6 (7%), and a combination of heroin and methadone in 9 (11%). Premature delivery was significantly more common in the group of pregnant addicts (21% vs. 6%); 49% of pregnant addicts were carriers of hepatitis C virus (HCV) and 14% of hepatitis B virus (HBV). Neonatal abstinence syndrome developed in 61 infants (7%) born to addicted mothers. There were 4 cases (4.6%) of early neonatal death; 7 neonates had 5-minute Apgar score < or = 7 (8%); 29 neonates had low birth weight for age (33%); and 7 neonates had congenital anomalies (8%). The risk of various congenital anomalies was 3-fold in the group of children born to addicted mothers.CONCLUSION:
Addiction pregnancies present a small but high-risk group according to perinatal outcome. Appropriate obstetric and neonatal care can reduce the rate of complications in these pregnancies and improve perinatal outcome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apgar Score
/
Pregnancy Complications
/
Pregnancy Complications, Infectious
/
Birth Weight
/
Neonatal Abstinence Syndrome
/
Pregnancy Outcome
/
Infant Mortality
/
Incidence
/
Croatia
/
Maternal Exposure
Type of study:
Incidence study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Country/Region as subject:
Europa
Language:
English
Journal:
Yonsei Medical Journal
Year:
2008
Type:
Article
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