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Acromegaly with Normal Insulin-Like Growth Factor-1 Levels and Congestive Heart Failure as the First Clinical Manifestation
Endocrinology and Metabolism ; : 395-401, 2015.
Article in English | WPRIM | ID: wpr-153715
ABSTRACT
The leading cause of morbidity and mortality in patients with acromegaly is cardiovascular complications. Myocardial exposure to excessive growth hormone can cause ventricular hypertrophy, hypertension, arrhythmia, and diastolic dysfunction. However, congestive heart failure as a result of systolic dysfunction is observed only rarely in patients with acromegaly. Most cases of acromegaly exhibit high levels of serum insulin-like growth factor-1 (IGF-1). Acromegaly with normal IGF-1 levels is rare and difficult to diagnose. Here, we report a rare case of an acromegalic patient whose first clinical manifestation was severe congestive heart failure, despite normal IGF-1 levels. We diagnosed acromegaly using a glucose-loading growth hormone suppression test. Cardiac function and myocardial hypertrophy improved 6 months after transsphenoidal resection of a pituitary adenoma.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pituitary Neoplasms / Arrhythmias, Cardiac / Acromegaly / Insulin-Like Growth Factor I / Growth Hormone / Mortality / Estrogens, Conjugated (USP) / Heart Failure / Hypertension / Hypertrophy Type of study: Prognostic study Limits: Humans Language: English Journal: Endocrinology and Metabolism Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pituitary Neoplasms / Arrhythmias, Cardiac / Acromegaly / Insulin-Like Growth Factor I / Growth Hormone / Mortality / Estrogens, Conjugated (USP) / Heart Failure / Hypertension / Hypertrophy Type of study: Prognostic study Limits: Humans Language: English Journal: Endocrinology and Metabolism Year: 2015 Type: Article