Ultrastructural changes of hepatic stellate cells in the space of Disse in alcoholic fatty liver
The Korean Journal of Internal Medicine
;
: 160-166, 2001.
Article
in English
| WPRIM
| ID: wpr-153772
ABSTRACT
BACKGROUND:
Hepatic stellate cell (HSC) has been suggested to play a role in fibrogenesis in alcoholic liver disease. We evaluate the correlation with fibrogenesis and ultrastructure of hepatic stellate cells in alcoholic fatty liver.METHODS:
We studied 6 patients with alcoholic fatty liver and 5 non-alcoholic fatty liver. The numbers of fat droplets in hepatic stellate cell was determined by electron microscopy. We also studied the grading of deposition of collagen fibers in the space of Disse. We were to evaluate the structure of hepatic stellate cells in the space of Disse by light and electron microscopy.RESULTS:
Wider distribution of fat droplets in hepatic stellate cells in alcoholic fatty liver than in normal liver. The hypertrophied endoplasmic reticulum in hepatic stellate cells is a prominent findings in alcoholic fatty liver. We observed basement membrane-like materials in patients with alcoholic fatty liver with hepatic fibrosis.CONCLUSION:
The results demonstrate that, in patients with alcoholic fatty liver by alcoholic liver injury, the hepatic stellate cells may play an important role in the fibrogenesis of perisinusoidal spaces in the liver.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Basement Membrane
/
Biopsy, Needle
/
Comparative Study
/
Microscopy, Electron
/
Probability
/
Prospective Studies
/
Collagen
/
Statistics, Nonparametric
/
Hepatocytes
Type of study:
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2001
Type:
Article
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