A Case of Crohn's Disease Showing Favorable Response to Induction and Maintenance Therapy with Methotrexate after Failure of Anti-tumor Necrosis Factor Therapy / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 231-236, 2015.
Article
in Korean
| WPRIM
| ID: wpr-153826
ABSTRACT
Thanks to the introduction of immumomodulators and biologics, therapeutic approaches in Crohn's disease have changed significantly during the past decade. Although new biologic therapy has dramatically improved the treatment of Crohn's disease, a substantial number of patients are refractory to these therapies or lose their initial response. Methotrexate (MTX) is a structural analogue of folic acid that can competitively inhibit the binding of dihydrofolic acid to the enzyme dihydrofolate reductase and has been widely used as immunomodulator in rheumatology area for patients with rheumatoid arthritis and psoriasis. Although MTX has also been shown to be an effective agent for remission induction and maintenance of remission in Crohn's disease, the use of MTX in Crohn's disease has not yet been reported in Korea. Herein, we report a case of Crohn's disease patient who was successfully treated with MTX after treatment failure with thiopurine and anti-tumor necrosis factor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Remission Induction
/
Crohn Disease
/
Tomography, X-Ray Computed
/
Methotrexate
/
Colonoscopy
/
Tumor Necrosis Factor-alpha
/
Infliximab
/
Immunosuppressive Agents
/
Antibodies, Monoclonal
Limits:
Adult
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2015
Type:
Article
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