Interaction between Genetic Polymorphisms of CYP2E1 & NAT1 and Smoking in Lung Cancer Development (Preliminary report) / 대한암학회지

ABSTRACT

PURPOSE: The interactive effects of genetic polymorphisms of cytochrome P4502E1 (CYP2E1) & N-acetyltransferase 1 (NAT1) and smoking on lung cancer development were evaluated in hospital based case-control study. MATERIALS AND METHODS: Male lung cancer patients (N= 157) and the male patients with no present or previous history of systemic illnesses who visited the urology department (N=138) were recruited (1998-1999). CYP2E1 & NAT1 genotypes were determined by PCR-RFLP method using RsaI and MboII digestion, respectively. RESULTS: CYP2E1 c2 or NAT1 *10 allele did not increased the risk of lung cancer. Heavy smokers (35CYP2E1 c2 or NAT1 *10 allele were at the higher risk compared with light smokers (0CYP2E1 or NAT1 genotypes and smoking were observed (p-for interaction= 0.003; <0.001 respectively). Heavy smokers with both c2 and *10 allele were at the higher risk compared with light smokers with other combined genotypes (OR=3.5, 95% CI=1.4-9.5) and interactive effect with smoking was observed (p-for interaction=0.003).

CONCLUSION:

These results suggest the gene-environment interaction between genetic polymorphisms of CYP2E1 & NAT1 and smoking in lung cancer development.