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Impact of Cyclooxygenase-2 Expression on the Survival of Glioblastoma / 대한방사선종양학회지
The Journal of the Korean Society for Therapeutic Radiology and Oncology ; : 145-150, 2007.
Article in English | WPRIM | ID: wpr-153995
ABSTRACT

PURPOSE:

To investigate the degree and effect of cyclooxygenase (COX)-2 expression on the survival of patients with glioblastoma multiforme (GM). MATERIALS AND

METHODS:

Between 1997 and 2006, thirty consecutive GM patients treated with surgery and postoperative radiotherapy (dose range 44~65.1 Gy, median dose 61.2 Gy) were included in the study. Three patients were excluded that discontinued radiotherapy before receiving a dose of 40 Gy due to mental deterioration. The expression of the COX-2 protein in surgical specimens was examined by immunohistochemical analysis. Survival analysis and verification were performed with respect to sex, age, performance status, resection extent, radiotherapy dose, and degree of COX-2 expression using the Kaplan-Meier method and the log rank test.

RESULTS:

The median length of follow-up was 13.3 months (range 6~83 months). Staining for COX-2 was positive in all patient samples. Staining for COX-2 that was positive for over 75% of the tumor cells was found in 24 patients. Staining for COX-2 that was positive in less than 25% of tumor cells was found in 3 patients (10.0%), staining for COX-2 that was positive in 25 to 50% of tumor cells was found in 1 patient (3.3%), staining for COX-2 that was positive in 50 to 75% of tumor cells was found in 2 patients (6.7%) and staining for COX-2 that was positive in 75 to 100% of tumor cells was found in 24 patients (80.0%). The median survival and two-year survival rate were 13.5 months and 17.5%, respectively. The survival rate was influenced significantly by the degree of resection (tumor removal by 50% or more) and radiotherapy dose (59 Gy or greater) (p0.05), and the two-year survival for these groups was 33.3 and 13.3%, respectively (p>0.05).

CONCLUSION:

The absence of a statistical correlation between the degree of COX-2 expression and survival in GM patients, despite the high rate of COX-2 positive tumor cells in the GM patient samples, requires further studies with a larger series to ascertain the prognostic value of the degree of COX-2 expression in GM patients.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiotherapy / Survival Rate / Follow-Up Studies / Prostaglandin-Endoperoxide Synthases / Glioblastoma / Cyclooxygenase 2 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: The Journal of the Korean Society for Therapeutic Radiology and Oncology Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiotherapy / Survival Rate / Follow-Up Studies / Prostaglandin-Endoperoxide Synthases / Glioblastoma / Cyclooxygenase 2 Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: The Journal of the Korean Society for Therapeutic Radiology and Oncology Year: 2007 Type: Article