Infusion-Related Toxicities of DMSO Containing Cryopreserved Blood / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 51-57, 1998.
Article
in Korean
| WPRIM
| ID: wpr-154096
ABSTRACT
PURPOSE:
We retrospectively evaluated infusion-related toxicities in the patients transfused with frozen-thawed blood mixed with dimethyl-sulfoxide (DMSO).METHODS:
The incidence and severity of infusion-related toxicities in the 25 patients transfused with frozen-thawed blood containing hematopoietic stem cells mixed with 10% DMSO were compaired with those of other 18 patients (11 patients;transfused with ABO-compatible allogeneic marrow blood without DMSO, 7 patients;transfused with platelet concentrates which were frozen with 6% DMSO and washed after thawing to remove DMSO).RESULT:
The median transfusion volume of blood containing DMSO was 280cc and that of blood without DMSO was 180cc. The infusion-related toxicities of blood containing DMSO were nausea (96%, 24/25), febrile sensation (88%, 22/25), vomiting (48%, 12/25), hematuria (32%, 8/25), dyspnea (16%, 4/25), convulsion (8%, 2/25), and sudden death (4%, 1/25). That of blood without DMSO was febrile sensation (5.6%, 1/18). The incidence of infusion-related toxicities of blood containing DMSO was significantly higher than that of blood without DMSO (p<0.05).CONCLUSION:
It could be suggestive that the infusion-related toxicities of blood containing DMSO was occured more frequently and severely than those of blood without DMSO.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seizures
/
Sensation
/
Vomiting
/
Blood Platelets
/
Bone Marrow
/
Hematopoietic Stem Cells
/
Dimethyl Sulfoxide
/
Incidence
/
Retrospective Studies
/
Death, Sudden
Type of study:
Incidence study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Blood Transfusion
Year:
1998
Type:
Article
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