Genetic Variations of Tyrosine Hydroxylase in the Pathogenesis of Hypertension
Electrolytes & Blood Pressure
;
: 21-26, 2016.
Article
in English
| WPRIM
| ID: wpr-154210
ABSTRACT
One of the major pathophysiological features of primary hypertension is an inappropriate activation of the sympathetic nervous system, which is mediated by excessive synthesis and secretion of catecholamine into the blood. Tyrosine hydroxylase (TH), a rate-limiting enzyme in the synthesis of catecholamine, has been highlighted because genetic variations of TH could alter the activity of the sympathetic nervous system activity and subsequently contribute to the pathogenesis of hypertension. Here, we discuss the role of TH as a regulator of sympathetic activity and review several studies that investigated the relationship between genetic variations of TH and hypertension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sympathetic Nervous System
/
Tyrosine
/
Tyrosine 3-Monooxygenase
/
Genetic Variation
/
Polymorphism, Single Nucleotide
/
Hypertension
Type of study:
Etiology study
Language:
English
Journal:
Electrolytes & Blood Pressure
Year:
2016
Type:
Article
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