Computerized Time Activity Analysis of Radionuclide Cerebral Angiography in Patients with Ischemic Cerebrovascular Disease

ABSTRACT

Radionuclide cerebral angiography is a indirect method of measuring cerebral blood flow in ischmic cerebrovascular disease, but conventional radionuclide cerebral angiogra phy has been interpretated by simple inspection without quantification. We designed this study to obtain the quantitative data via computerized time-activity analysis of the radionuclide cerebral angiography in region of interest. In 30 persons without evidence of cerebrovascular disease right/left ratios were 0.993+0.252(mean+ 2SD) in antenor cerebral artery territories of the cerebral hemisphere and 0.947 0.186(mean+2SD) in middle cerebral artery territories. Thirteen patients of 33 patients(39.4%) with ischemic cerebrovascular disease had right / left ratios that were beyond 2 standard deviation of the normal mean. We suggest this study is valuable in patients suspected Gf cerebrovascular disease while this method will require extensive study.