The Optimal Concentration of Ropivacaine in Combination with Butorphanol 50micro gram/ml for Patient-Controlled Epidural Analgesia / 대한마취과학회지

ABSTRACT

BACKGROUND: Opioids may be used in a dose-sparing capacity with local anesthetics to reduce the dose needed. This study examined the efficacy of different concentrations of ropivacaine combined with butorphanol 50 micro gram/ml to provide postoperative analgesia. METHODS: Sixty parturients were received epidural infusion with 0.075% ropivacaine (Group 1 n = 20), 0.1% ropivacaine (Group 2 n = 20) and 0.15% ropivacaine (Group 3 n = 20) in combination with butorphanol 50 micro gram/ml using patient-controlled epidural analgesia (PCEA) after cesarean section. PCEA was started with basal infusion of 4 ml of PCEA solution and 4 ml of bolus infusion at 10 min of lockout interval. Using a visual analogue scale (VAS) assessed the degree of pain and incidences of side effects were checked. RESULTS: Total infusion doses of ropivacaine were significantly higher in group 3, and butorphanol consumption were significantly lower in group 3 (P<0.05). The incidences of nausea, vomiting and sedation were significantly higher in group 1 (P<0.05). There were no significantly differences in VAS pain score and other side effects among the groups. CONCLUSIONS: This study suggests that 0.1% or 0.15% ropivacaine with butorphanol 50micro gram//ml for PCEA can provide the most effective analgesia with less side effects after cesarean section.