Three-month Treatment Response and Exacerbation in Chronic Obstructive Pulmonary Disease
Journal of Korean Medical Science
; : 54-59, 2015.
Article
in En
| WPRIM
| ID: wpr-154367
Responsible library:
WPRO
ABSTRACT
The aim of this study was to investigate relationships between acute exacerbation and Forced Expiratory Volume 1 second (FEV1) improvement after treatment with combined long-acting beta-agonist (LABA) and inhaled corticosteroid (ICS) in patients with chronic obstructive pulmonary disease (COPD). A total of 137 COPD patients were classified as responders or nonresponders according to FEV1 improvement after 3 months of LABA/ICS treatment in fourteen referral hospitals in Korea. Exacerbation occurrence in these two subgroups was compared over a period of 1 yr. Eighty of the 137 COPD patients (58.4%) were classified as responders and 57 (41.6%) as nonresponders. Acute exacerbations occurred in 25 patients (31.3%) in the responder group and in 26 patients (45.6%) in the nonresponder group (P=0.086). FEV1 improvement after LABA/ICS treatment was a significant prognostic factor for fewer acute exacerbations in a multivariate Cox proportional hazard model adjusted for age, sex, FEV1, smoking history, 6 min walk distance, body mass index, exacerbation history in the previous year, and dyspnea scale.Three-month treatment response to LABA/ICS might be a prognostic factor for the occurrence of acute exacerbation in COPD patients.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Recurrence
/
Spirometry
/
Bronchodilator Agents
/
Smoking
/
Forced Expiratory Volume
/
Treatment Outcome
/
Adrenal Cortex Hormones
/
Budesonide
/
Pulmonary Disease, Chronic Obstructive
/
Drug Therapy, Combination
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2015
Type:
Article