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Rhabdomyolysis in a Cyclosporine-treated Renal Transplant Recipient Who Received Atorvastatin as Replacement for Fluvastatin / 대한신장학회잡지
Korean Journal of Nephrology ; : 836-839, 2004.
Article in Korean | WPRIM | ID: wpr-154469
ABSTRACT
Statin-induced rhabdomyolysis is a frequent complication in renal transplant recipients receiving cyclosporine, but incidences are different between different types of statins. Statins have different pharmacokinetic properties. Atorvsatatin, simvastatin, lovastatin, and cerivastatin are all metabolized by the cytochrome P450 isoenzyme 3A4 and co-administration of cyclosporine which may inhibit cytochrome P450 isoenzyme 3A4, increases statin levels and therefore increases the risk of rhabdomyolysis. Fluvastatin is metabolized by cytochrome P450 isoenzyme 2C9 and no clinically significant interactions with cyclosporine have been reported. Atorvastatin with co-administration of cyclosporine in renal transplant patients may induce drug interactions, therefore we recommend the routine monitoring of muscle enzymes, in these cases. Here, we reported a case of rhabdomyolysis in a patient who received atorvastatin and cyclosporine with the review of the literature.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rhabdomyolysis / Transplantation / Lovastatin / Incidence / Cyclosporine / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Cytochrome P-450 Enzyme System / Drug Interactions / Atorvastatin Type of study: Incidence study / Prognostic study Limits: Humans Language: Korean Journal: Korean Journal of Nephrology Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Rhabdomyolysis / Transplantation / Lovastatin / Incidence / Cyclosporine / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Simvastatin / Cytochrome P-450 Enzyme System / Drug Interactions / Atorvastatin Type of study: Incidence study / Prognostic study Limits: Humans Language: Korean Journal: Korean Journal of Nephrology Year: 2004 Type: Article