Transforming growth factor-beta gene promoter polymorphism:its association with renal involvement in Henoch-Scholein Purpura in childhood / 소아과
Korean Journal of Pediatrics
;
: 523-527, 2008.
Article
in Korean
| WPRIM
| ID: wpr-154524
ABSTRACT
Purpose:
Several cytokines play important roles in the inflammatory process of Henoch-Scholein Purpura (HSP). It is likely that transforming growth factor-beta (TGF-beta) is involved in the pathogenesis of HSP. The purpose of this study is to investigate whether TGF-beta promoter polymorphism is associated with the renal involvement of childhood HSP.Methods:
Thirty-four patients younger than 15 years, who had been diagnosed with HSP, as well as 27 controls, were examined. Patients and controls were genotyped for TGF-beta C-509T by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).Results:
The T allelic frequencies in patients and controls showed no difference (45% vs. 48.8%). No allele or genotype differences between the group of HSP group and control group were observed. The frequencies of TGF-beta 509 genotypes TT, TC, and CC were no different between patients and controls (26% vs. 22%). The TT genotype of polymorphism of the TGF-beta C-509T gene had no relation to the susceptibility of children to HSP and renal involvement in HSP.Conclusion:
TGF-beta T allele may not be related to the susceptibility of children to HSP. The TT genotype of polymorphism of the TGF-beta C 509T gene does not appear to have an influence on renal involvement in childhood HSP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Purpura
/
Cytokines
/
Transforming Growth Factor beta
/
Alleles
/
Genotype
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2008
Type:
Article
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