Gastric mucosal immune response of Helicobacter pylori-infected children / 소아과
Korean Journal of Pediatrics
;
: 492-499, 2008.
Article
in Korean
| WPRIM
| ID: wpr-154529
ABSTRACT
Purpose:
Helicobacter pylori infection is one of the most common gastrointestinal infections worldwide; it almost invariably causes chronic gastritis. Pediatric studies may provide important insights into the mucosal immune response of H. pylori-infection, as children are not submitted to environmental factors such as alcohol, tobacco and anti-inflammatory medication. The aim of the present study was to investigate the mucosal immune response against H. pylori in clinically well-defined groups H. pylori-positive (divided into peptic ulcer disease and gastritis) and H. pylori-negative control.Methods:
Antral biopsies were obtained from 45 children undergoing an upper GI endoscopy for dyspeptic symptoms. T cells (CD3+, CD4+, CD8+) and B cells (CD20+) were analyzed by quantitative immunohistochemistry. The correlation of lymphocyte subsets of gastric mucosa with histology was evaluated.Results:
T cells (CD3+, CD4+, CD8+) and B cells (CD20+) were significantly increased in the lamina propria of H. pylori-positive group (p<0.01). CD8+ T cells were significantly increased in the lamina propria of the H. pylori-positive peptic ulcer disease (p<0.01). Within the epithelium, only CD4+ T cells were significantly increased in the H. pylori-positive group (p<0.01). Gastric histological parameters had a closer correlation with lymphocytes in the lamina propria than intraepithelial lymphocytes.Conclusion:
This study suggests that both T cells and B cells in the lamina propria play important roles in the local immune response of H. pylori-infected children. Furthermore, it remains to be elucidated whether CD8+ T cells in the lamina propria may contribute to peptic ulcer formation in H. pylori-infected children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organometallic Compounds
/
Peptic Ulcer
/
Nicotiana
/
Biopsy
/
Carbamates
/
Immunohistochemistry
/
B-Lymphocytes
/
Lymphocytes
/
T-Lymphocytes
/
Lymphocyte Subsets
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Pediatrics
Year:
2008
Type:
Article
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