Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits
Journal of Periodontal & Implant Science
;
: 86-95, 2017.
Article
in English
| WPRIM
| ID: wpr-15456
ABSTRACT
PURPOSE:
The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits.METHODS:
In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology.RESULTS:
Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm3 and 46.6 mm3, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037).CONCLUSIONS:
In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Dental Implants
/
Osseointegration
/
Collagen
/
Bone Substitutes
/
Transplants
/
Sinus Floor Augmentation
/
Maxillary Sinus
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Periodontal & Implant Science
Year:
2017
Type:
Article
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