SCN1A Gene Mutation and Adaptive Functioning in 18 Vietnamese Children with Dravet Syndrome
Journal of Clinical Neurology
;
: 62-70, 2017.
Article
in English
| WPRIM
| ID: wpr-154745
ABSTRACT
BACKGROUND AND PURPOSE:
Dravet syndrome is a rare and severe type of epilepsy in infants. The heterogeneity in the overall intellectual disability that these patients suffer from has been attributed to differences in genetic background and epilepsy severity.METHODS:
Eighteen Vietnamese children diagnosed with Dravet syndrome were included in this study. SCN1A variants were screened by direct sequencing and multiplex ligation-dependent probe amplification. Adaptive functioning was assessed in all patients using the Vietnamese version of the Vineland Adaptive Behavior Scales, and the results were analyzed relative to the SCN1A variants and epilepsy severity.RESULTS:
We identified 13 pathogenic or likely pathogenic variants, including 6 that have not been reported previously. We found no correlations between the presence or type of SCN1A variants and the level of adaptive functioning impairment or severity of epilepsy. Only two of nine patients aged at least 5 years had an adaptive functioning score higher than 50. Both of these patients had a low frequency of convulsive seizures and no history of status epilepticus or prolonged seizures. The remaining seven had very low adaptive functioning scores (39 or less) despite the variability in the severity of their epilepsy confirming the involvement of factors other than the severity of epilepsy in determining the developmental outcome.CONCLUSIONS:
Our study expands the spectrum of known SCN1A variants and confirms the current understanding of the role of the genetic background and epilepsy severity in determining the developmental outcome of Dravet syndrome patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Seizures
/
Status Epilepticus
/
Weights and Measures
/
Population Characteristics
/
Adaptation, Psychological
/
Epilepsies, Myoclonic
/
Asian People
/
Epilepsy
/
Multiplex Polymerase Chain Reaction
/
Genetic Background
Type of study:
Prognostic study
Limits:
Child
/
Humans
/
Infant
Language:
English
Journal:
Journal of Clinical Neurology
Year:
2017
Type:
Article
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