Correlation between Expression of p53 Protein and Prognostic Factors in Meningiomas
Korean Journal of Pathology
;
: 274-280, 1999.
Article
in Korean
| WPRIM
| ID: wpr-154785
ABSTRACT
Mutation of p53 tumor suppressor gene is now recognized as the most frequent genetic alteration in human neoplasms. Although meningiomas are common intracranial tumors, little is known about the clinical significance of p53 abnormalities in meningiomas. We studied 31 cases of meningioma to investigate the significance of p53 protein expression in meningiomas and its relationships with histological and clinical parameters and proliferative activity. Classical and atypical meningiomas were 16 (51.6%) and 15 cases (43.4%), respectively. p53 protein expression was detected in 4 (25.0%) of 16 classical, and 12 (80.0%) of 15 atypical meningiomas. p53 protein expression was correlated with Ki-67 staining index, atypical type, high histologic score, sheet pattern of the neoplastic cells, vascular proliferation, and male patient (p<0.05). In conclusion, immunohistochemical evaluation of p53 protein and histologic score of meningiomas are useful in assessing the prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Genes, Tumor Suppressor
/
Meningioma
Type of study:
Prognostic study
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
1999
Type:
Article
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