The Significance of Changes in Serum Prostate Specific Antigen Levels after a Transurethral Resection of the Prostate / 대한비뇨기과학회지
Korean Journal of Urology
;
: 704-707, 2005.
Article
in Korean
| WPRIM
| ID: wpr-155438
ABSTRACT
PURPOSE:
The serum prostate specific antigen (PSA) level is known to be related with the total prostate and cancer volumes. After a transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH), a decrease in the serum PSA level is expected. We investigated the relationship between the resected prostate specimen weight and serum PSA level. MATERIALS ANDMETHODS:
Between July 1998 and March 2003, 372 patients underwent a TURP for the treatment BPH. We performed studies, including digital rectal examination, urinary flow rate, international prostate symptom score, serum PSA levels, and transrectal ultrasound (TRUS) pre-and post-operatively. We compared the resected specimen weight of the prostate with the changes in the serum PSA level using correlation and regression tests as statistical methods.RESULTS:
Removal of 1gm of BPH tissue decreased the serum PSA the average level by 0.45 0.25ng/ml. In patients with BPH, there was a strong statistical correlation and a direct proportionality between the resected specimen weight and changes in the serum PSA level (p<0.05). Using the above mentioned statistical methods, the formula y=2.389+0.158x (x= resected specimen weight, y=changes in serum PSA levels) was derived. However, there was no statistical correlation between the two factors in prostate cancer patients.CONCLUSIONS:
An elevated serum PSA level in patients with BPH is mainly caused by the enlargement of the prostate transition zone. A statistically significant difference was noted between the pre-and post-operative serum PSA levels. However, in patients with prostate cancer, the serum PSA levels showed various postoperative changes. Some patients that underwent a TURP for BPH showed no match on the previously-mentioned formula, and these patients should be carefully followed up, with serum PSA level check-ups and/or a prostate biopsy considered.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostate
/
Prostatic Hyperplasia
/
Prostatic Neoplasms
/
Biopsy
/
Ultrasonography
/
Prostate-Specific Antigen
/
Transurethral Resection of Prostate
/
Digital Rectal Examination
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Urology
Year:
2005
Type:
Article
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