Clinicopathological Significance of Invasive Ductal Carcinoma with High Prevalence of CD44(+)/CD24(-/low) Tumor Cells in Breast Cancer
Korean Journal of Pathology
;
: 390-396, 2010.
Article
in English
| WPRIM
| ID: wpr-155463
ABSTRACT
BACKGROUND:
Epithelial tumor cells with a CD44(+)/CD24(-/low) immunoprofile may have the ability to cause breast cancer. We studied these cells and their clinicopathological significance.METHODS:
The clinicopathologic findings of 100 invasive ductal carcinoma (IDC) cases and 45 ductal carcinoma in situ (DCIS) cases were reviewed. CD44(+)/CD24(-/low) tumor cells were identified by immunohistochemistry, and their clinicopathological implications in IDC and DCIS were analyzed.RESULTS:
IDC with a high prevalence of CD44(+)/CD24(-/low) tumor cells was significantly associated with larger mass, higher grade, estrogen receptor (ER) negativity, and tumor cells with a higher frequency of metastasis. The proportion of CD44(+)/CD24(-/low) tumor cells in IDC, and its DCIS components was not significantly different, whereas the proportion of CD44(+)/CD24(-/low) tumor cells was higher in DCIS than in the DCIS component of IDC (p < 0.001).CONCLUSIONS:
IDC with a high prevalence of CD44(+)/CD24(-/low) tumor cells might correlate with aggressive features, such as ER and higher grades. Moreover, the proportion of CD44(+)/CD24(-/low) tumor cells in the DCIS components of IDC and DCIS might harbor different biology, which may lead to differences in cancer progression and early carcinogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Neoplastic Stem Cells
/
Biology
/
Breast
/
Breast Neoplasms
/
Immunohistochemistry
/
Prevalence
/
Carcinoma, Intraductal, Noninfiltrating
/
Hyaluronan Receptors
/
Carcinoma, Ductal
/
Estrogens
Type of study:
Prevalence study
/
Prognostic study
Language:
English
Journal:
Korean Journal of Pathology
Year:
2010
Type:
Article
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