Neuronal Functions of ESCRTs
Experimental Neurobiology
;
: 9-15, 2012.
Article
in English
| WPRIM
| ID: wpr-155510
ABSTRACT
The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission, microRNA function, viral budding, and the autophagy pathway in many tissues, including the nervous system. Indeed, dysfunctional ESCRTs are associated with neurodegeneration. However, it remains largely elusive how ESCRTs act in post-mitotic neurons, a highly specialized cell type that requires dynamic changes in neuronal structures and signaling for proper function. This review focuses on our current understandings of the functions of ESCRTs in neuronal morphology, synaptic plasticity, and neurodegenerative diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plastics
/
Endosomes
/
Autophagy
/
Neurodegenerative Diseases
/
Protein Transport
/
Dendrites
/
MicroRNAs
/
Endocytosis
/
Endosomal Sorting Complexes Required for Transport
/
Lysosomes
Language:
English
Journal:
Experimental Neurobiology
Year:
2012
Type:
Article
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